Dusting Powder Presentation

SERTACONAZOLE 2% W/W

Sertaconazole belongs to the imidazole class of antifungal drugs. It is used to treat fungal infections such as athlete’s foot. It is indicated to treat tinea pedis in immunocompromised patients of 12 years of age. They work by slowing the growth of fungi.

Indications

• Tinea pedis
• Vulvovaginal candidiasis
• Skin mycoses

Mechanism of Action

Sertaconazole inhibits cytochrome P-450 enzyme i.e. 14-alpha demethylase which involves in the conversion of lanosterol to ergosterol. Ergosterol is the component of fungal cell membrane. Sertaconazole inhibits the endogenous respiration and transformation of yeast to mycelial forms.

Pharmacokinetics

Absorption- It absorbed to lesser extent
Protein Binding- It shows 99% of proteins binding

Side Effects

• Burning
• Swelling
• Irritation
• Tenderness
• Discoloration
• Dry skin

Contraindication

• Contraindicated in pregnancy
• Contraindicated in people with known hypersensitivity